Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Apart from references to perception, words such asseeandlistenhave shared, non-literal meanings across diverse languages. Such cross-linguistic meanings have not been systematically investigated as they appear in their natural home — informal spoken interaction. We present a qualitative examination of the semantic associations of perception verbs based on recorded everyday conversation in thirteen diverse languages. Across these diverse communities, spontaneous interaction provides evidence for two commonly-discussed extensions of perception verbs — perception~cognition, hearing~linguistic communication — as well as illustrating other meanings and (...) functions (e.g., the use of perception verbs as discourse markers) that have been less appreciated heretofore. The range of usage that is readily observable in informal conversation makes it clear that this type of data must take center stage for the empirically grounded study of semantics. Moreover, these data suggest that commonalities in polysemous meanings may rely not only on universal cognition, but also on the universal exigencies of social interaction. (shrink)

Intuitively, there is a difference between knowledge and mere belief. Contemporary philosophical work on the nature of this difference has focused on scenarios known as “Gettier cases.” Designed as counterexamples to the classical theory that knowledge is justified true belief, these cases feature agents who arrive at true beliefs in ways which seem reasonable or justified, while nevertheless seeming to lack knowledge. Prior empirical investigation of these cases has raised questions about whether lay people generally share philosophers’ intuitions about these (...) cases, or whether lay intuitions vary depending on individual factors (e.g. ethnicity) or factors related to specific types of Gettier cases (e.g. cases that include apparent evidence). We report an experiment on lay attributions of knowledge and justification for a wide range of Gettier Cases and for a related class of controversial cases known as Skeptical Pressure cases, which are also thought by philosophers to elicit intuitive denials of knowledge. Although participants rated true beliefs in Gettier and Skeptical Pressure cases as being justified, they were significantly less likely to attribute knowledge for these cases than for matched true belief cases. This pattern of response was consistent across different variations of Gettier cases and did not vary by ethnicity or gender, although attributions of justification were found to be positively related to measures of empathy. These findings therefore suggest that across demographic groups, laypeople share similar epistemic concepts with philosophers, recognizing a difference between knowledge and justified true belief. (shrink)

“Toda interpretación pende, juntamente con lo interpretado, en el aire; no puede servirle de apoyo. Las interpretaciones solas no determinan el significado”Wittgenstein, Investigaciones filosóficas § 198IntroducciónLa obra del filósofo estadounidense David H. Finkelstein, Expression and the Inner, publicada originariamente en 2003 por Harvard University Press (2ª ed. 2008) puede ahora leerse en la versión española de Lino San Juan, editada por la ovetense KRK Ediciones con el título: La expr.

I. La Transcendance est la séparation absolue de notions absolues, et tenues comme absolues, en dépit de leur pluralité.II. L’impossibilité rationnelle de la transcendance tient en effet à ce que l’absolu étant un et unique, il est inadmissible que la pluralité, implicitement postulée par cette séparation, reste absolue sans contradiction.III. Ramenée à une analyse humaine du réel, ce n’est qu’un aspect de l’abstraction.

The complexity of equivalence relations has received much attention in the recent literature. The main tool for such endeavour is the following reducibility: given equivalence relations R and S on natural numbers, R is computably reducible to S if there is a computable function f:ω→ω that induces an injective map from R-equivalence classes to S-equivalence classes. In order to compare the complexity of equivalence relations which are computable, researchers considered also feasible variants of computable reducibility, such as the polynomial-time reducibility. (...) In this work, we explore Peq, the degree structure generated by primitive recursive reducibility on primitive recursive equivalence relations with infinitely many equivalence classes. In contrast with all other known degree structures on equivalence relations, we show that Peq has much more structure: e.g., we show that it is a dense distributive lattice. On the other hand, we also offer evidence of the intricacy of Peq, proving, e.g., that the structure is neither rigid nor homogeneous. (shrink)